Rapid Effector Function of Varicella-Zoster Virus Glycoprotein I-Specific CD4+ T Cells Many Decades after Primary Infection
Identifieur interne : 002B89 ( Main/Exploration ); précédent : 002B88; suivant : 002B90Rapid Effector Function of Varicella-Zoster Virus Glycoprotein I-Specific CD4+ T Cells Many Decades after Primary Infection
Auteurs : Gathsaurie Neelika Malavige [Royaume-Uni, Sri Lanka] ; Louise Jones [Royaume-Uni] ; Antony Paul Black [Royaume-Uni] ; Graham Stuart Ogg [Royaume-Uni]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2007.
Abstract
Glycoprotein I (gI) of varicella-zoster virus (VZV) contributes to viral virulence and is therefore a potentially important target for T cell control of viral replication. Persisting effector function of gI-specific T cells after primary infection has not been previously examined. We have shown that, many decades after infection, relatively high frequencies gI-specific interferon-γ responses are detectable ex vivo and are dominated by CD4+ T cells. We characterized the optimal peptide of the strongest response in our cohort showing restriction through DRB4*01. These findings are consistent with gIspecific CD4+ T cell involvement in the control of VZV replication.
Url:
DOI: 10.1086/511274
Affiliations:
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type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2007</date><biblScope unit="vol">195</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="660">660</biblScope><biblScope unit="page" to="664">664</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Glycoprotein I (gI) of varicella-zoster virus (VZV) contributes to viral virulence and is therefore a potentially important target for T cell control of viral replication. Persisting effector function of gI-specific T cells after primary infection has not been previously examined. We have shown that, many decades after infection, relatively high frequencies gI-specific interferon-γ responses are detectable ex vivo and are dominated by CD4+ T cells. We characterized the optimal peptide of the strongest response in our cohort showing restriction through DRB4*01. 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